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Transdermal patches (adhesive patches placed on the skin) may also be used to deliver a steady dose through the skin and into the bloodstream. Testosterone-containing creams and gels that are applied daily to the skin are also available, but absorption is inefficient (roughly 10%, varying between individuals) and these treatments tend to be more expensive. Individuals who are especially physically active and/or bathe often may not be good candidates, since the medication can be washed off and may take up to six hours to be fully absorbed. There is also the risk that an intimate partner or child may come in contact with the application site and inadvertently dose himself or herself; children and women are highly sensitive to testosterone and can suffer unintended masculinization and health effects, even from small doses. Injection is the most common method used by individuals administering AAS for non-medical purposes. [45]

Algae can be used to produce ' green diesel ' (also known as renewable diesel, hydrotreating vegetable oil [60] or hydrogen-derived renewable diesel) [61] through a hydrotreating refinery process that breaks molecules down into shorter hydrocarbon chains used in diesel engines. [60] [62] It has the same chemical properties as petroleum-based diesel [60] meaning that it does not require new engines, pipelines or infrastructure to distribute and use. It has yet to be produced at a cost that is competitive with petroleum . [61] While hydrotreating is currently the most common pathway to produce fuel-like hydrocarbons via decarboxylation/decarbonylation, there is an alternative process offering a number of important advantages over hydrotreating. In this regard, the work of Crocker et al. [63] and Lercher et al. [64] is particularly noteworthy. For oil refining, research is underway for catalytic conversion of renewable fuels by decarboxylation . [65] As the oxygen is present in crude oil at rather low levels, of the order of %, deoxygenation in petroleum refining is not of much concern, and no catalysts are specifically formulated for oxygenates hydrotreating. Hence, one of the critical technical challenges to make the hydrodeoxygenation of algae oil process economically feasible is related to the research and development of effective catalysts. [66] [67]

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